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Investigation of Differentiated Nasal Epithelial Responses to Infection with Clinical Isolates of Rhinovirus A and C

The nasal epithelium is the primary point of contact for inhaled respiratory viruses such as rhinovirus, respiratory syncytial virus, influenza, and coronavirus, among others. In order to establish infection, these viruses must engage their respective receptors located on host epithelial cells and begin replication.

Citation:
Watkinson RL, Bochkov YA, Gern JE, Iosifidis T, Looi K, Laing IA, Kicic A. Investigation of Differentiated Nasal Epithelial Responses to Infection with Clinical Isolates of Rhinovirus A and C. Methods Mol Biol. 2025;2903:113-39.

Keywords:
Asthma; Confocal microscopy; Cytokines; Epithelial barrier; Nasal epithelium; Pediatrics; Receptors; Rhinovirus; Viral infection; Wheeze

Abstract:
The nasal epithelium is the primary point of contact for inhaled respiratory viruses such as rhinovirus, respiratory syncytial virus, influenza, and coronavirus, among others. In order to establish infection, these viruses must engage their respective receptors located on host epithelial cells and begin replication.