Therapeutic development to accelerate malaria control through intentional intervention layering

The clinical development of novel vaccines, injectable therapeutics, and oral chemoprevention drugs has the potential to deliver significant advancements in the prevention of Plasmodium falciparum malaria. These innovations could support regions in accelerating malaria control, transforming existing intervention packages by supplementing interventions with imperfect effectiveness or offering an entirely new tool.

Citation:
Braunack-Mayer L, Nekkab N, Malinga J, Kelly SL, Ansah E, Moehrle JJ, Penny MA. Therapeutic development to accelerate malaria control through intentional intervention layering. Malar J. 2025;24(1):12.

Keywords:
Plasmodium falciparum; Intervention layering; Intervention mixing; Malaria; Modelling

Abstract:
The clinical development of novel vaccines, injectable therapeutics, and oral chemoprevention drugs has the potential to deliver significant advancements in the prevention of Plasmodium falciparum malaria. These innovations could support regions in accelerating malaria control, transforming existing intervention packages by supplementing interventions with imperfect effectiveness or offering an entirely new tool.