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Stability and age-specific patterns of rhinovirus circulation in children observed over 3 decades

Rhinoviruses (RV) are the most common respiratory viruses globally and a major cause of airway symptoms in children and individuals with asthma. Although more than 170 RV types exist across 3 species (RV-A, RV-B, RV-C), type-specific circulation patterns and age-related prevalence remain poorly defined.

Citation:
Gao Y, Bochkov YA, Lee KE, ……… Holt P, Homil K, Jackson DJ, …… Laing IA, Lemanske RF, Jr., Le Souëf PN, Liu AH, et al. Stability and age-specific patterns of rhinovirus circulation in children observed over 3 decades. J Allergy Clin Immunol. 2026.

Keywords:
DHR3 genotype; NIH ECHO cohort; Rhinovirus epidemiology; age-specific prevalence; antiviral targets; pediatric respiratory infections; respiratory virus stability; vaccine development; viral phylogenetics; virus circulation patterns.

Abstract:
Rhinoviruses (RV) are the most common respiratory viruses globally and a major cause of airway symptoms in children and individuals with asthma. Although more than 170 RV types exist across 3 species (RV-A, RV-B, RV-C), type-specific circulation patterns and age-related prevalence remain poorly defined.