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Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity.
This chapter describes the preparation of respiratory tract tissue from both mice and rats for the isolation of respiratory tract dendritic cells (RTDC).
The Pregnancy and Early Life Immunology team's overall research vision is targeted towards understanding immunological development during early life.
We compared the effect of a heterologous wP/aP/aP primary series (hereafter mixed wP/aP) versus a homologous aP/aP/aP primary schedule (hereafter aP-only) on antibody responses to co-administered vaccine antigens in infants and toddlers.
The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood.
The study aims to identify the mechanism for this so that this knowledge can be used to better treat asthma and allergies in both males and females.
This study is designed to identify the specific unique immune cell response that occurs in these children with recurrent disease.
We are studying immune cells from identical twins of which one suffers and one does not suffer from allergic disease to identify specific mechanisms that may play important roles in disease development.
Studies in Europe show exposure of pregnant women to high levels of microbial products stimulate immune function maturation in their offspring
This project investigates how cells of the immune system respond to substances to cause allergies to help develop new treatments.