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Novel GABAAR antagonists target networked gene hubs at the leading-edge in high-grade gliomas
Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.
Dr Alison McDonnell
Early Career Fellow
The interplay between sarcoma and surgery-induced wound healing
In this project, we are using systems biology approaches to map the wound healing response in sarcoma following surgery to identify new treatments that can prevent sarcoma relapse.