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Research

Burkholderia pseudomallei evades Nramp1 (Slc11a1)- and NADPH oxidase-mediated killing in macrophages and exhibits Nramp1-dependent virulence gene expression

Here we show that transfected macrophages stably expressing wild-type Nramp1 (Nramp1+) control the net replication of B. thailandensis, but not B. pseudomallei.

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Breastfeeding beyond the big smoke: Who provides support for mothers in rural Western Australia?

Antenatal group education is effective in supporting breastfeeding duration for rural women and should be a key priority for rural health service providers.

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The bioenergetics of inflammation: insights into obesity and type 2 diabetes

Diabetes mellitus is one of the most common chronic metabolic disorders worldwide, and its incidence in Asian countries is alarmingly high.

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An exposome perspective: Early-life events and immune development in a changing world

Here we review the historical origins of exposome research and define a new concept, the metaexposome

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Evolving Identification of Blood Cells Associated with Clinically Isolated Syndrome: Importance of Time since Clinical Presentation and Diagnostic MRI

This study aimed to identify a CIS peripheral blood signature that may provide clues for potential immunomodulatory approaches early in disease

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Clinical presentation of Attenuated Psychosis Syndrome in children and adolescents: Is there an age effect?

Older age at presentation of Attenuated Psychosis Syndrome was associated with less functional impairment, but age was not associated with psychotic symptoms

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Physician training programs significantly improve diagnosis in cases coded as anaphylaxis over time: A major factor compounding time-trend data?

We conducted an investigation of all cases coded as anaphylaxis presenting to the main tertiary PED in Perth, Australia, where all coding is performed by staff.

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Incidence of and risk factors for hospitalisations due to vascular complications: A population-based type 1 diabetes cohort (n=1316) followed into early adulthood

Determining the incidence of hospitalisations and risk factors for vascular complications experienced during early adulthood in patients with childhood T1D

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Early childhood development of boys with genital anomalies

We found no increased risk of poor development among boys with hypospadias or undescended testis

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Lurasidone for Adolescents With Complex Mental Disorders: A Case Series

Lurasidone is a new second generation (atypical) antipsychotic agent with unique receptor affinity and side-effect profiles, but limited literature is available on its use in adolescent populations. Contrasting with research treatment trials which typically recruit patients by stringent selection criteria, this case series examined the effects and tolerability of using lurasidone in adolescents within real-life clinical settings in treating complex cases who had not responded to other therapy options. We conducted a retrospective case-note audit of 6 adolescents aged 14 to 17 years old attending community child and adolescent mental health services (CAMHS) who were prescribed lurasidone.

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Risk of conduct and oppositional defiant disorder symptoms in offspring of parents with mental health problems: Findings from the Raine Study

Epidemiological data indicate that paternal and maternal mental health difficulties are predictors of conduct disorder (CD) and oppositional defiant disorder (ODD) in offspring. We tested the association between maternal anxiety and depressive symptoms and paternal emotional problems with CD and ODD symptoms in adolescent offspring aged 17.

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Meta-analysis of the neural correlates of vigilant attention in children and adolescents

Vigilant Attention (VA), defined as the ability to maintain attention to cognitively unchallenging activities over a prolonged period of time, is critical to support higher cognitive functions and many behaviours in our everyday life. Evidence has shown that VA rapidly improves throughout childhood and adolescence until young adulthood and tends to decline in older adulthood.

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Effectiveness, Acceptability, and Feasibility of Digital Health Interventions for LGBTIQ+ Young People: Systematic Review

Young people (aged 12-25 years) with diverse sexuality, gender, or bodily characteristics, such as those who identify as lesbian, gay, bisexual, transgender, intersex, or queer (LGBTIQ+), are at substantially greater risk of a range of mental, physical, and sexual health difficulties compared with their peers. Digital health interventions have been identified as a potential way to reduce these health disparities.

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Fetal alcohol spectrum disorder: the importance of assessment, diagnosis and support in the Australian justice context

The current article outlines how individuals with fetal alcohol spectrum disorder may experience inequities within the justice system

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Individualized prediction of transition to psychosis in 1,676 individuals at clinical high risk: Development and validation of a multivariable prediction model

The aim of the study was to develop and validate an individualized, clinically based prognostic model for forecasting transition to psychosis from a CHR-P stage

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Intellectual disability and psychotic disorders in children: Association with maternal severe mental illness and exposure to obstetric complications

Maternal severe mental illness and exposure to obstetric complications contribute separately to the risk of intellectual disability

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Longer-term increased cortisol levels in young people with mental health problems

Hair segment analyses revealed longer-term increased levels of cortisol in the past 3 months in early mental health problems

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Risk perception and risk-taking behaviour during adolescence: The influence of personality and gender

This study investigated the influence of personality characteristics and gender on adolescents' perception of risk and their risk-taking behaviour.

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Humility, inquisitiveness, and openness: key attributes for meaningful engagement with Nyoongar people

The rebuilding of trust requires the development of meaningful relationships in order to break down the barriers so as to increase access and develop culturally secure responses by services