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Asthma remission has emerged as a potential therapeutic goal. However, definitions of remission have primarily focused on adult populations, with limited consensus on how remission should be defined in children.
Preterm birth is associated with lifelong respiratory sequelae, yet our understanding of lung function trajectories across the lifespan remains limited. We aimed to identify patterns of spirometry development from childhood to early adulthood in survivors of very preterm birth using novel data-driven methods.
Concerns persist regarding the potential long-term effects of general anaesthesia on brain development in children. This narrative review summarises recent preclinical and clinical evidence (2019-25) and updates consensus messages.
Existing trajectory studies have emphasised large-airway indices, but chronic obstructive pulmonary disease (COPD) might originate in smaller airways. This study aimed to investigate mid-to-small-airway function trajectories, their associated factors, and COPD risk.
Critical Events in Anaesthetised Kids undergoing Tracheal Intubation (CRICKET) is a prospective, international multicentre observational study with the objective of capturing, assessing, and analysing critical events associated with tracheal intubation in children.
Dog ownership has been suggested to be positively associated with children's physical, social, and emotional development. This study investigated the effect of a mobile health dog-facilitated physical activity intervention on young children's social-emotional development and attachment to the family dog.
Adolescence represents a pivotal period for the development of early diabetes-related vascular complications, primarily driven by chronic hyperglycemia and associated metabolic disturbances. Metabolomics provides a promising tool to identify biomarkers reflecting these early changes.
The understanding of children's social and emotional development in middle childhood is critical to promote well-being throughout the life course. Children who fail to develop social and emotional competencies are more likely to experience difficulties in adulthood and, in the worst case, psychopathology. The current study will employ Cross-Lagged Network Models to investigate children's social and emotional development among Australian children aged 6 to 10 years.
In this paper we provide an integrative synthesis of eight systematic reviews that compromise our systematic review series entitled ‘Population Perspectives on Nurturing Relational Health from Early Life’. We reflect on what we know, what we don’t know, and what we need to know to better safeguard the interpersonal world of the child.
Antimicrobial resistance (AMR) is a global healthcare emergency, directly causing 1.3 million deaths per year and predicted to increase dramatically over the coming decades. Understanding the molecular mechanisms underpinning antibiotic resistance is central to approaches for AMR surveillance and diagnosis in a clinical laboratory.