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Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital MicrocephalyThe recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation.
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Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based StudyWe investigated whether childhood infection-related hospitalisation (IRH, a marker of severity) was associated with subsequent adult CVD hospitalisation.
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Folate pathway gene polymorphisms and risk of childhood brain tumors: Results from an Australian case-control studyRecent research suggests that maternal folic acid supplementation is associated with a reduced risk of childhood brain tumors (CBT); polymorphisms in folate...
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Early mortality and primary causes of death in mothers of children with intellectual disability or Autism spectrum disorderMothers of children with intellectual disability or autism spectrum disorder (ASD) have poorer health than other mothers.
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School performance in children with type 1 diabetes: a contemporary population-based studyOur aim was to examine the school performance of children with type 1 diabetes in comparison to their peers, exploring changes over time, and the impact of...
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Maternal Dietary Intake of Folate and Vitamins B6 and B12 During Pregnancy and Risk of Childhood Brain TumorsThis Australia-wide study examines whether maternal intake of folate and vitamins B6 and B12 during pregnancy is associated with development of brain tumors...
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Ultraviolet radiation exposure and serum vitamin D levels in young childrenThis paper examined the link between UV exposure and vitamin D production in young children to determine how long it takes for sun exposure to affect serum...
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Mesothelioma risk after 40 years since first exposure to asbestos: A pooled analysisThis paper discusses the risk of developing malignant mesothelioma more than 40 years after the first exposure to asbestos.
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The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young childrenThis paper reports on the shift in parental attitude to vaccination after 2010, due to an unprecedented increase in febrile reactions in children receiving...
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Does late childbearing increase the risk for behavioural problems in children? a longitudinal cohort studyThis study aimed to examine the relationship between advanced parental age and behavioural outcomes in offspring in a longitudinal cohort of children in WA.