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Australian First Nations children are at very high risk of early, recurrent, and persistent bacterial otitis media and respiratory tract infection. With the PREVIX randomised controlled trials, we aimed to evaluate the immunogenicity of novel pneumococcal conjugate vaccine (PCV) schedules.

Australian Aboriginal and/or Torres Strait Islander children in rural/remote areas suffer high rates of persistent otitis media (OM) from early infancy. We aimed to determine the proportion of Aboriginal infants living in an urban area who have OM and investigate associated risk factors.

Shortage of ear, nose, and throat specialists in public hospitals can result in delays in the detection and management of otitis media. This study introduced a new hospital-based telehealth service, named the Ear Portal, and investigated its role in improving access to specialist care.

Conserved vaccine candidate proteins from S.pneumoniae induce serum and salivary antibody responses in Aboriginal and non-Aboriginal children with history of OM

To assess the effects of adding a topical steroid to topical antibiotics in the treatment of people with chronic suppurative otitis media

To assess the effects of topical antibiotics for people with chronic suppurative otitis media.

To assess the effects of systemic antibiotics for people with chronic suppurative otitis media.

To assess the effects of topical antiseptics for people with chronic suppurative otitis media

To assess the effectiveness of antibiotics versus antiseptics for people with chronic suppurative otitis media.

These data provide evidence that otitis-prone children do not have impaired functional cell mediated immunity