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Research

Predicting disease progression in cystic fibrosis

Comprehensive scores incorporating clinical, lung function, imaging and laboratory data will become essential in the future for predicting disease progression and for use in clinical trials

Research

Cohort Profile: The New South Wales Child Development Study (NSW-CDS)-Wave 2 (child age 13 years)

The New South Wales Child Development Study was established to enable a life course epidemiological approach to identifying risk and protective factors

Research

Baseline incidence of adverse birth outcomes and infant influenza and pertussis hospitalisations prior to the introduction of influenza and pertussis vaccination

These baseline data are essential to assess the safety and effectiveness of influenza and pertussis vaccinations in pregnant women from the NT

Research

Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity

Our result highlighted that miRNA-target gene network contributes to human disease genetics in a cell type-specific manner

Research

Group A Streptococcus co-ordinates manganese import and iron efflux in response to hydrogen peroxide stress

Here, we demonstrate that group A Streptococcus (GAS) utilises Mn(II) import via MtsABC during conditions of hydrogen peroxide stress

Research

Severe and Complicated Varicella and Associated Genotypes 10 Years After Introduction of a One-Dose Varicella Vaccine Program

Severe hospitalized varicella still occurs with a 1-dose varicella program, although predominantly in unvaccinated children

Research

Features of the metabolic syndrome in late adolescence are associated with impaired testicular function at 20 years of age

Adolescents with features of metabolic disorder or insulin resistance show impaired testicular function and altered hormone levels

Research

Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort study

We aim to assess the impact of interpregnancy intervals on maternal and child health outcomes in high-income countries

Research

Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin

Our results show that TRM cells have a fundamental role in the surveillance of subclinical melanomas in the skin by maintaining cancer-immune equilibrium

Research

Vaccine acceptance: Science, policy, and practice in a ‘post-fact’ world

We must continue our efforts to promote vaccine acceptance and thus increase vaccination uptake, by fostering more effective vaccination communication