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News & Events
WA’s nation-leading immunisation program for babies slashes RSV hospital admissionsAn Australian-first study demonstrating the effectiveness of a new immunisation against respiratory syncytial virus (RSV) for babies found it to be almost 90 per cent effective in reducing hospitalisation rates and helped more than 500 WA families avoid a hospital stay.
Update on pneumococcal and meningococcal vaccine research
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News & Events
RSV responsible for one out of every 50 childhood deaths worldwideThe urgency for a world-first respiratory syncytial virus vaccine is at an all-time high.
News & Events
Help us build a new weapon in the fight against deadly fluAt just two years old, Lucy lost her fight against flu. With your generous help, we can finally beat influenza.
News & Events
Good bacteria ally in the fight against Strep AInnovative research aiming to prevent the spread of Strep A using ‘friendly’ bacteria in the throat has received a $1.5 million boost in the latest round of National Health and Medical Research Council grants.
Research
Cardiac monitoring safety assessment framework for early phase group a streptococcal vaccine trialsThis paper presents a comprehensive cardiac safety framework for early clinical development of Streptococcus pyogenes (Group A Streptococcus) vaccines, endorsed by the Strep A Vaccine Global Consortium and the Australian Strep A Vaccine Initiative. Given historical concerns about vaccine-associated acute rheumatic fever, we have established standardized echocardiography protocols integrated with clinical assessment for monitoring cardiac safety in early-phase vaccine trials.
Research
Respiratory Syncytial Virus Strain Evolution and Mutations in Western Australia in the Context of Nirsevimab ProphylaxisNirsevimab is a long-acting monoclonal antibody used to prevent respiratory syncytial virus (RSV) infection in infants and high-risk children. During the 2024 RSV season in Western Australia, 21 922 doses were administered to infants entering their first season and 1221 doses to at-risk children. In this context, the selection and spread of escape variants are a potential concern. This study aimed to investigate nirsevimab binding site mutations using clinical and wastewater data.
Research
Consistency of self-reported and documented historical influenza vaccination status of US healthcare workersHealthcare personnel (HCP) are a priority group for annual influenza vaccination. Few studies have assessed the validity of recall of prior influenza vaccination status among HCP, especially for more than one preceding season.
Research
Molecular Methodologies for Improved Polymicrobial Sepsis DiagnosisPolymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms.