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Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD)

The current prophylactic treatment to prevent rheumatic heart disease requires four-weekly intramuscular injection of a suspension of the poorly soluble benzathine salt form of penicillin G (BPG) often for more than 10 years. In seeking to reduce the frequency of administration to improve adherence, biodegradable polymer matrices have been investigated.

Rheumatic heart disease in Timor-Leste school students: an echocardiography-based prevalence study

The rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys. Community engagement is essential for ensuring follow-up and the effective delivery of secondary prophylaxis.

Scabies and risk of skin sores in remote Australian Aboriginal communities: A self-controlled case series study

The association between scabies and skin sores is highly significant and indicates a causal relationship

Rheumatic heart disease in pregnancy: How can health services adapt to the needs of Indigenous women? A qualitative study

Health systems did not meet the needs of pregnant Aboriginal women with rheumatic heart disease

Aural toilet (ear cleaning) for chronic suppurative otitis media

To assess the effects of aural toilet procedures for people with chronic suppurative otitis media

A prospective study of fetal head growth, autistic traits and autism spectrum disorder

This large population-based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits

Topical versus systemic antibiotics for chronic suppurative otitis media

To assess the relative effectiveness of topical versus systemic antibiotics for people with chronic suppurative otitis media

Associations between proposed local government liquor store size classifications and alcohol consumption in young adults

Young adults' alcohol consumption appears to be impacted by liquor store density and convenience, rather than outlet size

The school experiences of children and adolescents with type 1 diabetes in Western Australia

Elevated levels of emotional difficulties among school students with T1D and variable levels of support from school staff to assist these students to manage their diabetes at school

High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

High dose vitamin D supplementation is associated with a shift to a more inflammatory faecal microbiome and increased susceptibility to colitis