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Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized MiceIn this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression.
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In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in miceIn utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in...
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Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammationThese data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention
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Early-life exposure to electronic cigarettes: cause for concernThere are a multitude of ways that, with respect to early-life exposures and health, electronic nicotine delivery systems are a cause for concern
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Sexual dimorphism in lung function responses to acute influenza A infectionMales are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and...
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Chronic carbon dioxide exposure: an unrecognised health risk of climate change?Alexander Larcombe BScEnv (Hons) PhD Honorary Research Fellow Honorary Research Fellow Associate Professor Alexander Larcombe began work at The Kids
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Understanding how viral infection in early life impacts on lung function in adulthoodAlexander David Deborah Larcombe Martino Strickland BScEnv (Hons) PhD BSc PhD PhD Honorary Research Fellow Head, Chronic Diseases Research Head,
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Toxicity of different biodiesel exhausts in primary human airway epithelial cells grown at air-liquid interfaceBiodiesel is created through the transesterification of fats/oils and its usage is increasing worldwide as global warming concerns increase. Biodiesel fuel properties change depending on the feedstock used to create it.
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The effect of TNF treatment uptake on incident hospital admission in Western AustraliaTreatment strategies for juvenile idiopathic arthritis (JIA) have shifted significantly over the last 20 years. We examined the effect of the introduction of government-subsidised TNF inhibitor (TNFi) treatment on incident hospitalisation for JIA.
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Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeabilityHRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15