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Identified CCI-007 as a novel small molecule that displays rapid toxicity towards a subset of MLL-r, CALM-AF10 and SET-NUP214 leukemia cell lines
Our results identify a pretreatment tumor microenvironment that predicts response to immune checkpoint blockade, which can be therapeutically attained
In this study, we investigate the in vivo synergy between romidepsin and cytarabine
These findings suggest that tumor cells employ multiple epigenetic and genetic mechanisms to evade immune control
We found two known risk factors in a large cohort of children treated for ALL and identified other factors associated with venous thromboembolism
This systematic review shows that children treated with platinum analogues are at risk of developing hearing loss
In this review, we discuss the different subsets of tumor-infiltrating dendritic cells and their role in anti-tumor immunity
The ANZCHOG-BN is a new biobank network in Australasia that was developed to improve and streamline access to high-quality pediatric and AYA cancer biospecimens
Our findings shed light on the mechanisms of leukemia-induced bone loss
Our data demonstrate that CD8+XCR1neg DCs possess a unique pattern of endocytic receptors and a restricted TLR profile that is particularly enriched for TLR5